{"id":25742,"date":"2026-06-10T00:00:00","date_gmt":"2026-06-10T00:00:00","guid":{"rendered":"https:\/\/angelboss.com.br\/2026\/06\/10\/332314-descoberto-um-novo-polimorfo-da-indometacina\/"},"modified":"2026-06-10T00:00:00","modified_gmt":"2026-06-10T00:00:00","slug":"332314-descoberto-um-novo-polimorfo-da-indometacina","status":"publish","type":"post","link":"https:\/\/angelboss.com.br\/en\/2026\/06\/10\/332314-descoberto-um-novo-polimorfo-da-indometacina\/","title":{"rendered":"Descoberto um novo polimorfo da indometacina"},"content":{"rendered":"

\nA Rigaku Corporation, parceira global de solu\u00e7\u00f5es para sistemas anal\u00edticos de raios X e empresa da Rigaku Holdings Corporation (sede: Akishima, T\u00f3quio; CEO: Jun Kawakami; “Rigaku”), anunciou que os resultados de um projeto de pesquisa conjunta realizada com a Shionogi & Co., Ltd., JEOL Ltd. e Universidade Farmac\u00eautica Meiji foram publicados no Crystal Growth & Design<\/i>, peri\u00f3dico internacional de renome mundial na \u00e1rea de cristalografia.<\/p>\n

Este comunicado de imprensa inclui multim\u00e9dia. Veja o comunicado completo aqui: https:\/\/www.businesswire.com\/news\/home\/20260609774062\/pt\/<\/a><\/p>\n

\"Cover<\/p>\n

Cover of the June 2026 issue of Crystal Growth & Design, featuring this research.<\/p>\n<\/div>\n

\nEssa pesquisa descobriu um polimorfo anteriormente desconhecido (forma \u03ba<\/i>) da indometacina, um f\u00e1rmaco anti-inflamat\u00f3rio e de al\u00edvio da dor de amplo uso. A equipe da pesquisa tamb\u00e9m realizou uma an\u00e1lise estrutural e caracteriza\u00e7\u00e3o da forma cristalina rec\u00e9m-identificada. Embora a indometacina seja objeto de pesquisa farmac\u00eautica h\u00e1 anos, a descoberta de um novo polimorfo \u00e9 um evento extremamente raro, fazendo com que essa descoberta seja altamente significante tanto para a cristalografia quanto para as pesquisas farmac\u00eauticas.<\/p>\n

\nOs polimorfos cristalinos s\u00e3o estruturas cristalinas diferentes formadas pelo mesmo composto qu\u00edmico, resultando em varia\u00e7\u00f5es nas propriedades, como solubilidade e estabilidade. As diferen\u00e7as entre os polimorfos s\u00e3o um tema importante de pesquisa no desenvolvimento farmac\u00eautico, visto que afetam a qualidade do f\u00e1rmaco e a capacidade de fabrica\u00e7\u00e3o. Espera-se que o polimorfo rec\u00e9m-descoberto aprofunde o entendimento em futuras pesquisas farmac\u00eauticas.<\/p>\n

\nA an\u00e1lise estrutural nesse projeto de pesquisa foi realizada usando o m\u00e9todo MicroED com o XtaLAB Synergy-ED, difrat\u00f4metro de el\u00e9trons totalmente integrado, desenvolvido em conjunto pela Rigaku e pela JEOL Ltd. O polimorfo rec\u00e9m-descoberto consistiu de cristais extremamente pequenos, medindo menos de um micr\u00f4metro, tornando a an\u00e1lise estrutural dif\u00edcil ao usar m\u00e9todos de difra\u00e7\u00e3o de raios X convencionais. Ao aproveitar a tecnologia MicroED, a equipe de pesquisa determinou com sucesso a estrutura cristalina da nova forma \u03ba<\/i>.<\/p>\n

\nAl\u00e9m disso, a an\u00e1lise dos arranjos moleculares dentro do cristal revelou intera\u00e7\u00f5es intermoleculares que contribuem para a estabilidade do polimorfo. Esses achados demonstram a efic\u00e1cia da MicroED na descoberta de polimorfos n\u00e3o detectados anteriormente e destacam seu potencial quanto a melhorar a qualidade farmac\u00eautica e acelerar o desenvolvimento de f\u00e1rmacos.<\/p>\n

\nT\u00edtulo do artigo: Descoberta de um novo polimorfo, forma \u03ba<\/i>, da indometacina
\n
Peri\u00f3dico: Crystal Growth & Design
\n
<\/i>DOI: https:\/\/doi.org\/10.1021\/acs.cgd.5c01534<\/a><\/p>\n

Parceiros de pesquisa
\n
<\/b>Shionogi & Co., Ltd.
\n
https:\/\/www.shionogi.com\/global\/en\/<\/a><\/p>\n

\nJEOL Ltd.
\n
https:\/\/www.jeol.com\/<\/a><\/p>\n

\nUniversidade Farmac\u00eautica Meiji
\n
https:\/\/www.my-pharm.ac.jp\/en\/<\/a><\/p>\n

Sobre a Rigaku Group
\n
<\/b>Desde a sua funda\u00e7\u00e3o em 1951, os profissionais de engenharia do grupo Rigaku dedicam-se a beneficiar a sociedade com tecnologias de ponta, principalmente nas suas \u00e1reas principais de an\u00e1lise t\u00e9rmica e de raios X. Com presen\u00e7a em 136 pa\u00edses e regi\u00f5es e cerca de 2.000 colaboradores em 9 opera\u00e7\u00f5es globais, a Rigaku \u00e9 uma parceira de solu\u00e7\u00f5es para a ind\u00fastria e institutos de pesquisa e an\u00e1lise. Nossa participa\u00e7\u00e3o nas vendas internacionais atingiu aproximadamente 70%, mantendo ao mesmo tempo uma participa\u00e7\u00e3o de mercado excepcionalmente alta no Jap\u00e3o. Juntamente com nossos clientes, continuamos a desenvolver e crescer. \u00c0 medida que as aplica\u00e7\u00f5es se expandem de semicondutores, materiais eletr\u00f4nicos, baterias, meio ambiente, recursos naturais, energia, ci\u00eancias da vida para outros campos de alta tecnologia, a Rigaku concretiza inova\u00e7\u00f5es para “Melhorar o Nosso Mundo, Impulsionando Novas Perspectivas”.
\n
Para mais detalhes, acesse: rigaku-holdings.com\/english<\/a><\/p>\n

\nO texto no idioma original deste an\u00fancio \u00e9 a vers\u00e3o oficial autorizada. As tradu\u00e7\u00f5es s\u00e3o fornecidas apenas como uma facilidade e devem se referir ao texto no idioma original, que \u00e9 a \u00fanica vers\u00e3o do texto que tem efeito legal.<\/p>\n

\"\"<\/span><\/p>\n

Ver a vers\u00e3o original em businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20260609774062\/pt\/<\/a><\/span><\/p>\n

Contato:<\/b><\/p>\n

Contato de imprensa:
\n<\/b><\/p>\n

Sawa Himeno\n<\/p>\n

Diretora do departamento de comunica\u00e7\u00f5es da Rigaku Holdings Corporation\n<\/p>\n

prad@rigaku.co.jp<\/a><\/p>\n

Fonte: <\/strong>BUSINESS WIRE<\/a>\"\"<\/p>","protected":false},"excerpt":{"rendered":"

– Pesquisa conjunta envolvendo a Rigaku publicada no Crystal Growth & Design –<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[315],"tags":[349,358,454,324,352,351,323],"class_list":["post-25742","post","type-post","status-publish","format-standard","category-noticias-corporativas-dino","tag-arte","tag-educacao","tag-industrias-de-bens-intermediarios","tag-negocios","tag-saude-e-bem-estar","tag-sociedade","tag-tecnologia"],"yoast_head":"\nDescoberto um novo polimorfo da indometacina - Portal Masculino de Moda, Beleza, Luxo and Business - Angel Boss<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/angelboss.com.br\/en\/2026\/06\/10\/332314-descoberto-um-novo-polimorfo-da-indometacina\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descoberto um novo polimorfo da indometacina - 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